blood flow 1st T-500ml/min, term-600ml/min
anatomical changes of muscular spiral vessel to flaccid vessel
1-12 weeks:
Invasion by the trophoblastic and fibrinoid tissue.
trophoblastic plague in the lumen of spiral arteries is release thus sudden increase of blood flow towards intervillous space.
12-20weeks:
invasion of trophoblastic tissue to intramyometrial segment of spiral arteries causing further reducein resistance of blood flow to placenta
(MID TRIMESTER FALL IN MOTHER BP)
Called FLACCID TRANSFORMATION OF SPIRAL ARTERY
- lack smooth muscle so less response to vasoactive components
- increase perfussion
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